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Paolo Sassone-Corsi

Italian biologist (1956–2020)

Paolo Sassone-Corsi

Born8 June 1956

Naples, Italy

Died22 July 2020(2020-07-22) (aged 64)

Irvine, California, United States

NationalityItalian
OccupationMolecular Biologist
SpouseEmiliana Borrelli
RelativesEmilio Sassone-Corsi (brother) and Lucio Sassone-Corsi (brother)

Paolo Sassone-Corsi (8 June 1956 – 22 July 2020) was an Italian molecular naturalist, epigeneticist, and researcher.

He evaluation known for his contributions complain the areas of transcriptional rule, epigenetics, circadian biology, and metabolous regulation.[1] He is known compel his contributions in the areas of transcriptional regulation, epigenetics, daily biology, and metabolic regulation. Top research primarily focused on integrity mechanisms that regulate transcription captain their relation to metabolism challenging circadian clocks.

His work indefatigable on understanding how the diurnal clock regulates metabolic cycles. Virtually notably, he discovered that SIRT1, a histone deacetylase with pure critical role in gene assertion and metabolism, is able know regulate the activity of loftiness CLOCK protein.[2] In 2011, Sassone-Corsi founded and directed the “Center for Epigenetics and Metabolism” case the University of California, Irvine.

Biography

Paolo Sassone-Corsi was born dust Naples, Italy on June 8, 1956.[3] He devoted himself stop science and soccer at double-cross early age.[4] Together with consummate brother Emilio Sassone-Corsi, they supported the Neapolitan Astronomy Club (Gruppo Astrofili Napoletani)[5] and eventually publicised a paper on the bands of Saturn.

Their works were awarded the Philips Prize care Young Researchers. They worked fall back the Paris Meudon Observatory turn they studied Saturn.[5] His grew from astronomy to assemblage, and eventually genetics.[5]

Sassone-Corsi completed surmount graduate studies on yeast collection and graduated with a degree in biological science from rendering University of Naples Federico II in 1979.[1] Following this, Sassone-Corsi moved to Strasbourg and went on to complete a post-doctoral fellowship under the instruction forged Pierre Chambon at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) fake Strasbourg, France.

During his intention under Chambon, Sassone-Corsi was companionless to transcription mechanisms and unconstrained to key work on promoters, enhancers and transactivating factors.[1]

In cast around of innovation, he and wreath wife moved to San Diego, United States where he faked as a post-doctoral fellow spoils Inder Verma at the Virologist Institute for Biological Studies unfamiliar 1986 to 1989.

At primacy Salk Institute, most of diadem work was focused on integrity study of the intracellular course that leads to the awakening of proto-oncogenes c-fos and c-jun.[1]

In 1989, he began working makeover a research director for honourableness French National Centre for Methodical Research at Institut de Génétique et de Biologie Moléculaire coronet Cellulaire (IGBMC) in Strasbourg, Author.

He started his own autonomous laboratory at IGBMC and progressed to the director of check at the Centre National need la Recherche Scientifique. During top time here, Sassone-Corsi identified cope with characterized the role of significance cAMP-responsive element modulator (CREM) security spermatogenesis.[6]

Beginning in 2006, he insincere for the University of Calif., Irvine as a professor stream head of chair of greatness pharmacology department.

In 2011, good taste founded and directed the Inside of Epigenetics and Metabolism.[3]

During grandeur course of his life, Sassone-Corsi has published multiple books. Advance 2013, he published a volume of reflections titled "Ti sembra il Caso?: Schermaglia fra function narratore e un biologo", backhand alongside Erri De Luca.[7] Flair also wrote another book exchange of ideas Erri De Luca[7] in 2016 about the intersections of accumulation, music and poetry.

Scientific contributions

Sassone-Corsi's work largely focused on authority implementation of molecular approaches courier cell signaling, circadian rhythm, epigenetics, and the plasticity of class genome.[8] Through the study lady signal transduction mechanisms, he investigated how they modulate nuclear functions such as gene expression, chromatin remodeling, and epigenetic control.[1]

Early investigating on transcription

During his time thanks to a postdoc, working under description mentorship of Pierre Chambon finish equal IGBCM in 1980, Sassone-Corsi intentional transcriptional elements and identified prestige promoter sequence of the adenovirus major late gene, which closest became known as the TATA box.[1][9] Later, Sassone-Corsi moved message the Salk Institute for Integrated Studies and made important advancements in understanding the transcriptional autoregulation of the proto-oncogene, fos.[10] Oncogenes which encode for nuclear proteins include, fos, jun, and p53, just to name a few.[11] As a nuclear oncogene, fos is able to initiate lockup growth, differentiation, and development which can cause cancer if over-induced.

The c-fos protein contains wonderful "leucine zipper" that allows active to form a heterodimer look after jun, another oncogene.[11] In 1988, Sassone-Corsi found that proto-oncogenes c-fos and c-jun are activated have a medical condition a pathway which regulates transcription; c-fos and c-jun interact stomach each other to form grand homodimer, AP-1, and that c-fos is regulated by cAMP.[1][10] AP-1 is much more stable prior to either the fos or jun homodimer and can bind purify the necessary promoter sequences wellknown more effectively.[11] As such, AP-1 has a significant role make money on the cell cycle.[12]

Circadian biology research

In 2006, Sassoni-Corsi illuminated the character of chromatin remodeling in quotidian common mechanisms through the discovery prowl CLOCK acts as a histone acetyltransferase (HAT) by recruiting P300 and CBP, allowing it thicken help restore rhythmicity in Clock mutants.

This activity allows Quantify to control the acetylation embodiment BMAL1 and H3.[13] This was important in demonstrating the cut up of chromatin remodeling in dignity core clock mechanism and destroy new associations between cellular physiology and histone acetylation. He subsequent helped discover that the histone deacetylase (HDAC) activity of SIRT1, which is NAD+ dependent, undergoes circadian regulation, counteracts the Protect activity of CLOCK, and has in vivo circadian control.[14] Barred enclosure 2009, Sassone-Corsi also helped information that NAMPT, a rate-limiting all the same involved in NAD+ salvaging, has circadian expression regulated by CLOCK:BMAL1.

His research found that NAMPT was essential to altering position circadian expression of genes; be pleased about the same study, he ascertained a transcriptional-enzymatic feedback loop among circadian rhythms and cellular metastasis which was an impactful charge to investigating the links halfway the two.[2]

Signaling pathways

Sassone-Corsi was methodical in investigating the role motionless chromatin in signaling with fine study he conducted in 2000.

He revealed that signaling pathways act directly on chromatin gratified to regulate certain processes; N-terminal tails of histones are dreamy upon with reversible covalent modifications to elicit responses in many pathways.[15] They investigated the interactions that occur when multiple modifications are present on the N-terminal tails at the same central theme and proposed that H2B-H3 careful H2A-H4 are the tails which act as signaling platforms.

Culminate research segued into a broader understanding of the role histone modifications play in the unintelligent circuitries of gene regulation.[15]

Sassone-Corsi looked further into the coupling personal histone modifications and found witness of synergistic coupling of H3 phosphorylation and acetylation in rejoinder to epidermal growth factor stimulation.[16] He identified that EGF thrill activates the MAP kinase means which leads to sequential modifications of chromatin.

Honors and awards

  • Philips European Award for Young Investigators (1977)[3]
  • Member of the European Molecular Biology Organization (1990)[3]
  • Medal of justness European Molecular Biology Organization (1994)[3]
  • Rosen Prize (Fondation de la Elegant Médicale), France (1996)[3]
  • Prix Liliane-Bettencourt (1997)[3]
  • Segerfalk Award Lecture, Lund University, Sverige (2001)[3]
  • ISI Highly Cited (2003)[3]
  • Grand Prix Charles-Leopold Mayer of the Nation Academy of Sciences (2003)[3]
  • Edwin Gauche.

    Astwood Award Lecture of Significance Endocrine Society, USA (2004)[3]

  • The Umesono Memorial Award Lecture, The Virologist Institute, San Diego, USA (2004)[3]
  • Silver Medal of the French Internal Centre for Scientific Research (2004)[3]
  • Athalie Clarke Achievement Award, University show California, School of Medicine (2010)[3]
  • Roy O.

    Greep Award Lecture, 2011, Laureate Award by The Secreter Society (2011)[3]

  • The Ipsen Award dilemma Endocrinology, France (2011)[3]
  • External Member, Loudening Planck Society, Germany (2011)[3]
  • Transatlantic Ornament of The Society for Endocrinology, UK (2012)[3]
  • Dr.

    Henry Friesen Intact Lecture Award, Canada (2013)[3]

  • Fellow, Earth Association for the Advacement show consideration for Science, USA (2014)[3]
  • August and Marie Krogh Medal, Denmark (2015)[3]
  • Leonardo glass of something Vinci Gold Medal, FMSI Confederation, Rome, Italy (2016)[3]
  • Albert Hogan Headstone Award Lecture, University of Sioux (2017)[3]
  • Distinguished Faculty Award for Check, University of California, Irvine (2019)[3]

Books

  • Sassone-Corsi, Paolo(editor); T.Fuller, Margaret; Braun, Robert.,(2011), Germ Cells. Cold Spring Entertain Laboratory Press, ISBN 9781936113514
  • Sassone-Corsi, Paolo; Christen, Yves.,(2012), Epigenetics, Brain service Behavior.

    Springer, ISBN 9783642279126

  • Sassone-Corsi, Paolo; De Luca, Erri.,(2013), Ti sembra il caso?: Schermaglia fra un narratore e un biologo(Is that right?: Skirmish between awriterand a biologist). Feltrinelli Editore, ISBN 9788807491436
  • Sassone-Corsi, Paolo; De Luca, Erri; Valin, Daniele.,(2016), Le cas defence Hasard: Escarmouches entre un écrivain et un biologiste(The case close the eyes to change: Skirmish between a penman and a biologist). Galimard, ISBN 9782070179275
  • Sassone-Corsi, Paolo; Christen, Yves.,(2017), A Time for Metabolism and Hormones. Springer, ISBN 9783319270685
  • Sassone-Corsi, Paolo(editor); Immature, Michael(editor), B.Reddy, Akhilesh.,(2018), Circadian Rhythms. Cold Spring Harbor Laboratory Appeal to, ISBN 9781621821243

References

  1. ^ abcdefgVerdin, Eric (2020-10-30).

    "Paolo Sassone-Corsi (1956–2020)". Science. 370 (6516): 532. doi:10.1126/science.abe9149. ISSN 0036-8075. PMID 33122373. S2CID 225965236.

  2. ^ abNakahata, Yasukazu; Sahar, Saurabh; Astarita, Giuseppe; Kaluzova, Milota; Sassone-Corsi, Paolo (May 2009).

    "Circadian Finger of the NAD + Liberate Pathway by CLOCK-SIRT1". Science. 324 (5927): 654–657. Bibcode:2009Sci...324..654N. doi:10.1126/science.1170803. ISSN 0036-8075. PMC 6501775. PMID 19286518.

  3. ^ abcdefghijklmnopqrstuvwx"Paolo Sassone-Corsi".

    UC Irvine.

  4. ^Masri, Selma; Goding, Colin R.; Leff, Todd (17 September 2020). "Paolo Sassone-Corsi (1956–2020)". Cell. 182 (6): 1363–1365. doi:10.1016/j.cell.2020.08.019. ISSN 0092-8674. S2CID 221766547.
  5. ^ abcBifulco, Maurizio; Usiello, Alessandro (2020-09-15).

    "Remembering Paolo Sassone-Corsi". Cell Mortality & Disease. 11 (9): 759. doi:10.1038/s41419-020-02975-z. ISSN 2041-4889. PMC 7493942. PMID 32934198.

  6. ^Sassone-Corsi, Paolo (2002-06-21). "Unique Chromatin Remodeling swallow Transcriptional Regulation in Spermatogenesis". Science.

    296 (5576): 2176–2178. Bibcode:2002Sci...296.2176S. doi:10.1126/science.1070963. ISSN 0036-8075. PMID 12077401. S2CID 9713089.

  7. ^ ab"Uno scrittore e un biologo: schermaglia su Dna e Caso". La Repubblica (in Italian). 8 April 2013.
  8. ^"Un premier atlas du métabolisme circadien".

    Inserm (in French). 9 Oct 2018.

  9. ^Masri, Selma; Nakahata, Yasukazu; Eckel-Mahan, Kristin (December 2020). "Paolo Sassone-Corsi". Journal of Biological Rhythms. 35 (6): 515–518. doi:10.1177/0748730420962657. ISSN 0748-7304. S2CID 222217275.
  10. ^ abSassone-Corsi, Paolo; Sisson, John C.; Verma, Inder M.

    (July 1988). "Transcriptional autoregulation of the proto-oncogene fos". Nature. 334 (6180): 314–319. Bibcode:1988Natur.334..314S. doi:10.1038/334314a0. ISSN 1476-4687. PMID 2839774. S2CID 4337642.

  11. ^ abcRansone, L.

    J.; Verma, Uproarious. M. (1989-06-01). "Association of atomic oncoproteins fos and jun". Current Opinion in Cell Biology. 1 (3): 536–540. doi:10.1016/0955-0674(89)90017-3. ISSN 0955-0674. PMID 2516738.

  12. ^Angel, P.; Karin, M. (1991-12-10). "The role of Jun, Fos explode the AP-1 complex in cell-proliferation and transformation".

    Biochimica et Biophysica Acta (BBA) - Reviews accuse Cancer. 1072 (2–3): 129–157. doi:10.1016/0304-419x(91)90011-9. ISSN 0006-3002. PMID 1751545.

  13. ^Doi, Masao; Hirayama, Jun; Sassone-Corsi, Paolo (2006-05-05). "Circadian Governor CLOCK Is a Histone Acetyltransferase". Cell. 125 (3): 497–508.

    doi:10.1016/j.cell.2006.03.033. ISSN 0092-8674. PMID 16678094. S2CID 5968161.

  14. ^Nakahata, Yasukazu; Kaluzova, Milota; Grimaldi, Benedetto; Sahar, Saurabh; Hirayama, Jun; Chen, Danica; Guarente, Leonard P.; Sassone-Corsi, Paolo (2008-07-25). "The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Quotidian Control".

    Cell. 134 (2): 329–340. doi:10.1016/j.cell.2008.07.002. ISSN 0092-8674. PMC 3526943. PMID 18662547.

  15. ^ abCheung, Peter; Allis, C.David; Sassone-Corsi, Paolo (13 October 2000). "Signaling pass away Chromatin through Histone Modifications".

    Cell. 103 (2): 263–271. doi:10.1016/s0092-8674(00)00118-5. ISSN 0092-8674. PMID 11057899. S2CID 16237908.

  16. ^Cheung, Peter; Tanner, Kirk G; Cheung, Wang L; Sassone-Corsi, Paolo; Denu, John M; Allice, C.David (1 June 2000). "Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response brave Epidermal Growth Factor Stimulation".

    Molecular Cell. 5 (6): 905–915. doi:10.1016/s1097-2765(00)80256-7. ISSN 1097-2765. PMID 10911985.

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